Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | CDK7 | P50613 | 5/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.43 |
| ▸ | RET | P07949 | 6/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | PAK4 | O96013 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12606269 | 0.89 | IGF1R (0.62) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL27613622 | 0.84 | SYK (0.61) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1777660 | 0.82 | IGF1R (0.67) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL5070002 | 0.80 | IGF1R (0.61) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL22067931 | 0.79 | IGF1R (0.67) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1777423 | 0.79 | IGF1R (0.67) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL12606337 | 0.79 | IGF1R (0.66) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL1777888 | 0.78 | IGF1R (0.65) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL12605817 | 0.78 | IGF1R (0.59) | IGF1RSYKGSK3BCDK7AURKB | |
| SCHEMBL5618430 | 0.78 | SYK (0.58) | IGF1RSYKGSK3BCDK7AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1665809-A | Azaindoles | AVENTIS PHARMA LTD (GB) | 2005-09-07 | — | — | CN | claimed |
| CN-100509811-C | Azaindoles | AVENTIS PHARMA LTD (GB) | 2009-07-08 | — | — | CN | disclosed |
| CN-1665809-A | Azaindoles | AVENTIS PHARMA LTD (GB) | 2005-09-07 | — | — | CN | disclosed |