Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526431 | 0.86 | HTT (0.47) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL6520461 | 0.85 | POLB (0.40) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL4342251 | 0.84 | POLB (0.39) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL4341979 | 0.84 | POLB (0.54) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL6673594 | 0.82 | MEN1 (0.48) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL27635574 | 0.81 | POLB (0.42) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL12846469 | 0.79 | KMT2A (0.42) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL12846470 | 0.79 | POLB (0.40) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL4344549 | 0.78 | POLB (0.48) | POLBHTTKMT2AMEN1MAPT | |
| SCHEMBL4341826 | 0.78 | HSPA5 (0.46) | POLBHTTKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |