Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526431 | 0.88 | HTT (0.47) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL4341979 | 0.84 | POLB (0.54) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL27616627 | 0.82 | POLB (0.43) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL10597378 | 0.81 | SMN1; SMN2 (0.62) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL27635574 | 0.81 | POLB (0.42) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL4341826 | 0.80 | HSPA5 (0.46) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL6251887 | 0.80 | NPC1 (0.46) | MEN1MAPTKMT2ASMN1; SMN2HTT | |
| SCHEMBL4347487 | 0.80 | EPHX1 (0.56) | MEN1KMT2ASMN1; SMN2HTTRAB9A | |
| SCHEMBL12846470 | 0.79 | POLB (0.40) | MEN1MAPTKMT2APOLBSMN1; SMN2 | |
| SCHEMBL6250660 | 0.79 | CNR1 (0.52) | MEN1MAPTKMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |