Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CHAT | P28329 | 2/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (Z)-1,2-Diphenylethene SCHEMBL443 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL442 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL22712863 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL9134296 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL9488270 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL9488275 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL347707 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL21847984 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL9134305 | 0.93 | MAOB (0.73) | MAOBNFE2L2CYP19A1MAOACYP11B1 | |
| (Z)-1,2-Diphenylethene SCHEMBL23852642 | 0.89 | MAOB (0.69) | MAOBNFE2L2CYP19A1MAOACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1817354-B | Injection of manchurian wildginge and astragalus root and its preparing method | SANMIN PHARMACEUTICAL CO LTD SICHUAN | 2010-04-28 | — | — | CN | claimed |
| CN-1817354-A | Injection of manchurian wildginge and astragalus root and its preparing method | SANMIN PHARMACEUTICAL CO LTD S (CN) | 2006-08-16 | — | — | CN | claimed |
| CN-1634250-A | Compound injectio of Chinese angelica and astragalus root and its preparing process | SICHUAN LESHAN SANMIN PHARMACE (CN) | 2005-07-06 | — | — | CN | claimed |
| CN-1817354-B | Injection of manchurian wildginge and astragalus root and its preparing method | SANMIN PHARMACEUTICAL CO LTD SICHUAN | 2010-04-28 | — | — | CN | disclosed |
| CN-1817354-A | Injection of manchurian wildginge and astragalus root and its preparing method | SANMIN PHARMACEUTICAL CO LTD S (CN) | 2006-08-16 | — | — | CN | disclosed |
| CN-1634250-A | Compound injectio of Chinese angelica and astragalus root and its preparing process | SICHUAN LESHAN SANMIN PHARMACE (CN) | 2005-07-06 | — | — | CN | disclosed |