Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 4/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ATP4A | P20648 | 2/20 | 0.35 |
| ▸ | ATP4B | P51164 | 2/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619679 | 0.90 | SRC (0.49) | PRKCQPRKCDLYNSRCAPP | |
| SCHEMBL27638700 | 0.81 | APP (0.39) | SRCAPPMCHR1 | |
| SCHEMBL28754797 | 0.81 | SRC (0.49) | PRKCQPRKCDSRCAPPALDH1A1 | |
| SCHEMBL28757790 | 0.79 | SRC (0.35) | SRCAPPALDH1A1CYP3A4 | |
| SCHEMBL27638790 | 0.78 | HRH3 (0.41) | SRCAPPHTR2CMCHR1 | |
| SCHEMBL27638695 | 0.78 | CYP2A6 (0.41) | SRCAPPMCHR1 | |
| SCHEMBL27638696 | 0.77 | SRC (0.40) | SRCAPPALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19029379 | 0.73 | HDAC6 (0.57) | APP | |
| SCHEMBL27638690 | 0.70 | SRC (0.40) | SRCAPP | |
| SCHEMBL4941352 | 0.70 | PRKCQ (0.60) | PRKCQPRKCDPRKCBLCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | claimed |
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | disclosed |