Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619679 | 0.80 | SRC (0.49) | SRCAPPHDAC6 | |
| SCHEMBL27638700 | 0.79 | APP (0.39) | SRCAPPHDAC6 | |
| SCHEMBL27638695 | 0.78 | CYP2A6 (0.41) | SRCAPPCYP2C19HDAC6CYP2D6 | |
| SCHEMBL27619682 | 0.77 | PRKCQ (0.43) | SRCAPPCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL28754797 | 0.74 | SRC (0.49) | SRCABL1APPCYP3A4ALDH1A1 | |
| SCHEMBL28757790 | 0.72 | SRC (0.35) | SRCAPPCYP3A4ALDH1A1KDM4E | |
| SCHEMBL27638790 | 0.71 | HRH3 (0.41) | SRCAPP | |
| SCHEMBL19029379 | 0.69 | HDAC6 (0.57) | APPHDAC6MAPT | |
| SCHEMBL27638690 | 0.66 | SRC (0.40) | SRCABL1APP | |
| SCHEMBL19029329 | 0.64 | HPGDS (0.38) | APPCYP3A4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | claimed |
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | disclosed |