Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TACR3 | P29371 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647979 | 0.90 | KDM4E (0.44) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL648635 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL28754990 | 0.80 | HSD11B1 (0.39) | ALDH1A1MAPTGPR84GCGRTACR3 | |
| SCHEMBL650101 | 0.74 | ERBB2 (0.42) | GPR84GCGRTACR3TLR8HSD11B1 | |
| SCHEMBL25720193 | 0.71 | KDM4E (0.61) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL12495846 | 0.70 | TLR8 (0.54) | KDM4EALDH1A1LMNAGLAHPGD | |
| SCHEMBL12495851 | 0.69 | TLR8 (0.60) | GPR84TLR8HSD11B1PSMB5 | |
| SCHEMBL23070173 | 0.68 | KDM4E (0.65) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL28499792 | 0.67 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTGLA | |
| SCHEMBL647774 | 0.67 | HSD11B1 (0.43) | ALDH1A1MAPTGPR84GCGRTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1646497-A | Novel arylimidazoles and related compounds as modulators of the C5a receptor | NEUROGEN CORP (US) | 2005-07-27 | — | — | CN | disclosed |