Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537001 | 0.92 | NPC1 (0.58) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| SCHEMBL27848727 | 0.92 | NPC1 (0.58) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| SCHEMBL18561699 | 0.92 | NPC1 (0.58) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| SCHEMBL15758248 | 0.90 | NPC1 (0.60) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| SCHEMBL3289909 | 0.90 | NPC1 (0.58) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| Fluoride SCHEMBL28559395 | 0.88 | NPC1 (0.58) | NPC1RAB9ADHODHSLC6A2SLC6A4 | |
| Bicarbonate SCHEMBL4410582 | 0.88 | KMO (0.61) | NPC1RAB9ADHODHKMOHAO1 | |
| Bicarbonate SCHEMBL4407651 | 0.88 | KMO (0.61) | NPC1RAB9ADHODHKMOHAO1 | |
| Bicarbonate SCHEMBL9436080 | 0.88 | KMO (0.61) | NPC1RAB9ADHODHKMOHAO1 | |
| Hydrogen Peroxide SCHEMBL28451101 | 0.88 | NPC1 (0.52) | NPC1RAB9ADHODHKMOHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108778766-A | Method for carrying out part dyeing to plastic part | 科思创德国股份有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108290820-A | Method for recovering aromatic alcohol from melt polymerization and system for recovering same | 沙特基础工业全球技术有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-104136508-B | Prepare for the method with low stress and the film of optical property in photoelectric device | 科思创德国股份有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-104231254-B | For the method producing polycarbonate compositions | 沙特基础全球技术有限公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105473223-A | Heterogeneous catalysts for the transesterification of aromatic alcohols; and methods of making and use thereof | SABIC INNOVATIVE PLASTICS IP BV | 2016-04-06 | — | — | CN | disclosed |
| CN-103003050-B | Apparatus and method for producing products from pigment-containing polymer mixtures | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-24 | — | — | CN | disclosed |
| CN-105189604-A | Production of a polycarbonate with limited metal residuals | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104231254-A | Process for the manufacture of polycarbonate compositions | SABIC INNOVATIVE PLASTICS IP | 2014-12-24 | — | — | CN | disclosed |
| CN-104136508-A | Process for the production of low stress and optical quality film for use in opto-electronic devices | BAYER MATERIALSCIENCE AG | 2014-11-05 | — | — | CN | disclosed |
| CN-103748259-A | A process for multi-layer continuous roll-to-roll coating | BAYER SOUTH EAST ASIA PTE LTD | 2014-04-23 | — | — | CN | disclosed |
| CN-103221229-A | Multilayer decorative film | BAYER IP GMBH | 2013-07-24 | — | — | CN | disclosed |
| CN-103003050-A | Apparatus and method for producing products from pigment-containing polymer mixtures | BAYER MATERIALSCIENCE AG | 2013-03-27 | — | — | CN | disclosed |
| CN-101429277-B | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG | 2013-03-27 | — | — | CN | disclosed |
| CN-102442910-A | Process for preparing diaryl carbonates from dialkyl carbonates | BAYER MATERIALSCIENCE AG | 2012-05-09 | — | — | CN | disclosed |
| CN-102224010-A | Security feature in security or value documents | BAYER MATERIALSCIENCE AG | 2011-10-19 | — | — | CN | disclosed |
| CN-102196920-A | ID card with laser engraving resistance | BAYER MATERIALSCIENCE AG | 2011-09-21 | — | — | CN | disclosed |
| CN-102164753-A | Use of plastic films in colour laser printing | BAYER MATERIALSCIENCE AG | 2011-08-24 | — | — | CN | disclosed |
| CN-1712450-B | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG | 2010-05-26 | — | — | CN | disclosed |
| CN-101429277-A | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG (DE) | 2009-05-13 | — | — | CN | disclosed |
| CN-1712450-A | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG (DE) | 2005-12-28 | — | — | CN | disclosed |