Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 16/20 | 0.45 |
| ▸ | CCR7 | P32248 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890953 | 0.89 | KMT2A (0.53) | KMT2ACXCR2L3MBTL1PKMNPSR1 | |
| SCHEMBL27714932 | 0.87 | KMT2A (0.40) | KMT2ACXCR2CCR7L3MBTL1PKM | |
| SCHEMBL27605617 | 0.86 | L3MBTL1 (0.43) | KMT2ACXCR2L3MBTL1HTR6 | |
| SCHEMBL490032 | 0.84 | CXCR2 (0.47) | KMT2ACXCR2CCR7 | |
| SCHEMBL28010834 | 0.83 | KMT2A (0.54) | KMT2ACXCR2CCR7 | |
| SCHEMBL27605804 | 0.83 | L3MBTL1 (0.46) | KMT2AL3MBTL1HTR6 | |
| SCHEMBL490008 | 0.78 | NPC1 (0.48) | KMT2ACXCR2CCR7 | |
| SCHEMBL1487070 | 0.76 | CXCR2 (0.43) | KMT2ACXCR2CCR7 | |
| SCHEMBL1487162 | 0.76 | CXCR2 (0.44) | KMT2ACXCR2CCR7 | |
| SCHEMBL1487166 | 0.75 | CXCR2 (0.44) | KMT2ACXCR2CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159555-A | Pyrimidyl sulfonaminde derivative and its use for the treatment of chemokine mediated diseases | ASTRAZENECA AB | 2011-08-17 | — | — | CN | disclosed |
| CN-100345829-C | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-101048401-A | Pyrimidine sulfonamide derivatives as chemokine receptor modulators | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | CN | disclosed |
| CN-1681795-A | Pyrimidyl sulfonamide derivatives as chemokine receptor modulators | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |