Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809526 | 0.89 | ALDH1A1 (1.00) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL11146599 | 0.87 | ALDH1A1 (0.96) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL27356016 | 0.84 | KMT2A (0.82) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL13479737 | 0.83 | ALDH1A1 (0.79) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL28170494 | 0.83 | POLB (0.79) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL31315673 | 0.81 | ALDH1A1 (0.77) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL13479738 | 0.80 | KMT2A (0.74) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL28298885 | 0.80 | KMT2A (0.74) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL13479809 | 0.79 | ALDH1A1 (0.68) | KMT2APOLBALDH1A1MAPTNPC1 | |
| SCHEMBL13479721 | 0.79 | KMT2A (0.72) | KMT2APOLBALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100586927-C | Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase | NOVARTIS AG | 2010-02-03 | — | — | CN | disclosed |
| CN-1741986-A | Amide derivatives and their use as inhibitors of 11-beta hydroxysteroid dehydrogenase | NOVARTIS AG (CH) | 2006-03-01 | — | — | CN | disclosed |