Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27820035 | 0.89 | PLA2G2D (0.37) | PLA2G2DPLA2G2CGABBR2GABBR1TSHR | |
| Oxalic Acid SCHEMBL27974806 | 0.86 | GABBR2 (0.38) | PLA2G2DPLA2G2CGABBR2GABBR1ALDH1A1 | |
| Oxalic Acid SCHEMBL27784989 | 0.83 | TSHR (0.35) | GABBR2GABBR1TSHR | |
| Oxalic Acid SCHEMBL28201642 | 0.76 | TSHR (0.37) | GABBR2GABBR1ALDH1A1TSHR | |
| SCHEMBL28224948 | 0.76 | — | — | |
| SCHEMBL5488959 | 0.74 | TSHR (0.43) | ALDH1A1TSHR | |
| SCHEMBL6957697 | 0.72 | LPAR3 (0.42) | PLA2G2DGABBR2GABBR1ALDH1A1TSHR | |
| SCHEMBL6956386 | 0.72 | LPAR3 (0.42) | PLA2G2DGABBR2GABBR1ALDH1A1TSHR | |
| SCHEMBL20672347 | 0.70 | PPARD (0.44) | ALDH1A1TSHR | |
| SCHEMBL1496456 | 0.70 | TSHR (0.55) | PLA2G2DPLA2G2CGABBR2GABBR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709322-A | Tricyclic compound as anticancer | 百时美施贵宝公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-1780643-B | Antiviral phosphonate analogs | GILEAD SCIENCES INC | 2012-04-25 | — | — | CN | disclosed |
| CN-101591281-A | Phosphonate compounds having immunomodulatory activity | GILEAD SCIENCES INC (US) | 2009-12-02 | — | — | CN | disclosed |
| CN-101410120-A | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES INC (US) | 2009-04-15 | — | — | CN | disclosed |
| CN-1780630-A | Phosphonate compounds having immunomodulatory activity | GILEAD SCIENCES INC (US) | 2006-05-31 | — | — | CN | disclosed |
| CN-1780643-A | Antiviral phosphonate analogs | GILEAD SCIENCES INC (US) | 2006-05-31 | — | — | CN | disclosed |
| CN-1780631-A | anticancer phosphonate analogs | GILEAD SCIENCES INC (US) | 2006-05-31 | — | — | CN | disclosed |