SCHEMBL27627360

SCHEMBL27627360

Cc1ccccc1-n1nc2cccc(C)c2n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
KDM4E B2RXH2 3/20 0.42
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 2/20 0.42
MAPT P10636 2/20 0.42
HPGD P15428 2/20 0.42
MEN1 O00255 1/20 0.42
USP2 O75604 1/20 0.42
ALOX15 P16050 1/20 0.42
CASP1 P29466 1/20 0.42
CACNA1B Q00975 1/20 0.42
APBA1 Q02410 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HSD17B10 Q99714 1/20 0.42
LMNA P02545 3/20 0.41
ADORA3 P0DMS8 1/20 0.40
ADORA2A P29274 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9269046 0.86 POLB (0.56) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL18719287 0.86 NPC1 (0.52) TSHRNPC1RAB9AKDM4EALDH1A1
SCHEMBL29486731 0.81 KDM4E (0.61) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL27647521 0.76 NPC1 (0.51) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL11163613 0.76 NPC1 (0.55) NPC1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL16141027 0.76 KMT2A (0.44) TSHRNPC1RAB9AKDM4EALDH1A1
SCHEMBL31223179 0.75 RAB9A (0.39) NPC1RAB9AALDH1A1KMT2AMAPT
SCHEMBL30778372 0.74 NPC1 (0.53) TSHRNPC1RAB9AKDM4EALDH1A1
SCHEMBL5423166 0.74 NPC1 (0.53) TSHRNPC1RAB9AKDM4EALDH1A1
SCHEMBL3624606 0.74 NPC1 (0.52) NPC1RAB9AKDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1761787-A Oxidation system comprising macrocyclic metal complexes, method for the production and use thereof LANXESS B V (NL) 2006-04-19 CN disclosed