Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18479755 | 0.96 | KDM4E (0.76) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL18479757 | 0.87 | KDM4E (0.76) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL8439255 | 0.87 | KDM4E (0.70) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL18440872 | 0.85 | ALDH1A1 (0.83) | KDM4EMAPK1NPSR1MAPTHSD17B10 | |
| SCHEMBL15331425 | 0.83 | MAPK1 (0.76) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL24113579 | 0.82 | MAPK1 (0.74) | KDM4EMAPK1RECQLMDM2SMN1; SMN2 | |
| SCHEMBL16028019 | 0.82 | KDM4E (0.67) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL638044 | 0.81 | MAPK1 (1.00) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL638043 | 0.81 | MAPK1 (1.00) | KDM4EMAPK1RECQLMDM2TDP1 | |
| SCHEMBL19013926 | 0.81 | MAPT (0.71) | KDM4EMAPK1RECQLMDM2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101503408-B | 8-(3-amino-piperidin-1-yl)-xanthines | BEOEHRINGER INGELHEIM PHARMA GMBH & CO KG | 2013-04-24 | — | — | CN | disclosed |
| CN-102964347-A | 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments | BOEHRINGER INGELHEIM PHARMA | 2013-03-13 | — | — | CN | disclosed |
| CN-101503408-A | 8-(3-amino-piperidin-1-yl)-xanthines | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-101503409-A | 8-(3-amino-piperidin-1-yl)-xanthines, the production thereof and the use of the same as medicaments | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | CN | disclosed |
| CN-100522962-C | 8- [ 3-amino-piperidin-1-yl ] -xanthines, process for their preparation and their use as pharmaceutical preparations | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-05 | — | — | CN | disclosed |
| CN-1675212-A | 8- [ 3-amino-piperidin-1-yl ] -xanthines, process for their preparation and their use as pharmaceutical preparations | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-09-28 | — | — | CN | disclosed |