Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 6/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060147 | 0.82 | NR1H4 (0.60) | NR1H4HSD17B10LMNANR1I2ALDH1A1 | |
| SCHEMBL14267822 | 0.81 | AR (0.49) | ARKIF11TMPRSS4KDRTRPV1 | |
| SCHEMBL11143595 | 0.78 | HSD17B10 (0.54) | NR1H4KIF11TMPRSS4KDRTRPV1 | |
| SCHEMBL20205053 | 0.78 | TAS2R14 (0.49) | ARKIF11KDRTRPV1PDK2 | |
| SCHEMBL1421027 | 0.78 | AR (0.50) | ARKIF11KDR | |
| SCHEMBL22435123 | 0.77 | AR (0.43) | ARKIF11KDRTRPV1PDK2 | |
| SCHEMBL6153068 | 0.76 | KDR (0.61) | ARTMPRSS4KDRTRPV1LMNA | |
| SCHEMBL2094292 | 0.76 | MAPT (0.53) | ARKIF11TMPRSS4LMNAHTT | |
| SCHEMBL14267826 | 0.76 | AR (0.45) | ARKIF11KDRTRPV1PDK2 | |
| SCHEMBL14606494 | 0.76 | TMPRSS4 (0.41) | NR1H4TMPRSS4HSD17B1HSD17B2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875002-B | Phenyl derivatives as PPAR agonists | HOFFMANN LA ROCHE | 2011-08-03 | — | — | CN | disclosed |
| CN-1875002-A | Phenyl derivatives as PPAR agonists | HOFFMANN LA ROCHE (CH) | 2006-12-06 | — | — | CN | disclosed |
| CN-1809541-A | Aniline derivatives | HOFFMANN LA ROCHE (CH) | 2006-07-26 | — | — | CN | disclosed |