Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.44 |
| ▸ | ULK1 | O75385 | 6/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131784 | 0.89 | MKNK1 (0.46) | MKNK1MKNK2MALT1TLR7 | |
| SCHEMBL3130704 | 0.86 | PDE4A (0.45) | MKNK1MKNK2ADORA3ADORA2AADORA1 | |
| SCHEMBL3131813 | 0.85 | MKNK1 (0.39) | MKNK1MKNK2ADORA3ADORA2AADORA1 | |
| SCHEMBL6276985 | 0.84 | KDR (0.46) | MKNK1ULK1KDRMKNK2ADORA3 | |
| SCHEMBL3137469 | 0.82 | PDE4A (0.50) | MKNK1MKNK2MALT1 | |
| SCHEMBL3137715 | 0.82 | PDE4A (0.41) | MALT1TLR7 | |
| SCHEMBL3141393 | 0.82 | TLR7 (0.43) | ULK1MALT1TLR7 | |
| SCHEMBL3128339 | 0.81 | PDE4A (0.40) | MKNK1MKNK2ADORA3ADORA2AADORA1 | |
| SCHEMBL3145980 | 0.81 | PDE4A (0.40) | MKNK1MKNK2ADORA3ADORA2AMALT1 | |
| SCHEMBL3141374 | 0.80 | PDE4A (0.39) | MKNK1MKNK2MALT1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688580-A | 2-Trifluoromethyl-6-aminopurine derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2005-10-26 | — | — | CN | claimed |
| CN-1688580-A | 2-Trifluoromethyl-6-aminopurine derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2005-10-26 | — | — | CN | disclosed |