Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131784 | 0.87 | MKNK1 (0.46) | MKNK1MKNK2TLR7PDE4APDE4B | |
| SCHEMBL3130704 | 0.86 | PDE4A (0.45) | MKNK1MKNK2TLR7ADORA3ADORA2A | |
| SCHEMBL27630786 | 0.84 | MKNK1 (0.44) | KDRULK1MKNK1MKNK2MERTK | |
| SCHEMBL3131813 | 0.84 | MKNK1 (0.39) | MKNK1MKNK2AXLMERTKTLR7 | |
| SCHEMBL3137715 | 0.84 | PDE4A (0.41) | TLR7PDE5APDE4APDE1APDE1B | |
| SCHEMBL3137469 | 0.82 | PDE4A (0.50) | MKNK1MKNK2PDE5APDE4APDE1A | |
| SCHEMBL3128339 | 0.81 | PDE4A (0.40) | MKNK1MKNK2TLR7ADORA3ADORA2A | |
| SCHEMBL3145980 | 0.80 | PDE4A (0.40) | MKNK1MKNK2TLR7ADORA3ADORA2A | |
| SCHEMBL3141374 | 0.79 | PDE4A (0.39) | MKNK1MKNK2TLR7PDE5APDE4A | |
| SCHEMBL6276981 | 0.79 | TLR7 (0.42) | MKNK1MKNK2MERTKTLR7ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529049-A2 | DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-05-11 | — | — | EP | claimed |
| WO-2004014913-A2 | DERIVATIVES OF 2-TRIFLUORMETHYL-6-AMINOPURINE AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-02-19 | — | — | WO | claimed |