Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 7/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CCNK | O75909 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27632522 | 1.00 | MCHR1 (0.44) | MCHR1NOX1ALOX5CCNKCCNA2 | |
| SCHEMBL27652689 | 0.86 | NOX1 (0.39) | MCHR1NOX1ALOX5CCNKCCNA2 | |
| SCHEMBL27652688 | 0.86 | NOX1 (0.39) | MCHR1NOX1ALOX5CCNKCCNA2 | |
| SCHEMBL6877517 | 0.82 | NOX1 (0.51) | MCHR1NOX1ADRA2AMEN1KMT2A | |
| SCHEMBL6877520 | 0.82 | NOX1 (0.51) | MCHR1NOX1ADRA2AMEN1KMT2A | |
| SCHEMBL6456969 | 0.77 | MCHR1 (0.52) | MCHR1ADRA2A | |
| Trifluoroacetic Acid SCHEMBL6873701 | 0.76 | MCHR1 (0.46) | MCHR1ADRA2A | |
| SCHEMBL27653039 | 0.75 | MCHR1 (0.38) | MCHR1CCNKCCNA2CDK2CDK12 | |
| SCHEMBL27653038 | 0.75 | MCHR1 (0.38) | MCHR1CCNKCCNA2CDK2CDK12 | |
| SCHEMBL27652735 | 0.74 | MCHR1 (0.40) | MCHR1CCNKCCNA2CDK2CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | disclosed |
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |