Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941832 | 0.89 | PARP1 (0.83) | PARP1 | |
| SCHEMBL2763674 | 0.88 | PARP1 (0.85) | PARP1 | |
| SCHEMBL5125923 | 0.87 | PARP1 (1.00) | PARP1 | |
| SCHEMBL5131208 | 0.86 | PARP1 (1.00) | PARP1 | |
| SCHEMBL4208087 | 0.85 | PARP1 (0.75) | PARP1 | |
| SCHEMBL5125334 | 0.84 | PARP1 (1.00) | PARP1 | |
| SCHEMBL5131347 | 0.84 | PARP1 (1.00) | PARP1 | |
| SCHEMBL2765387 | 0.84 | PARP1 (0.76) | PARP1 | |
| SCHEMBL4206310 | 0.84 | PARP1 (0.78) | PARP1 | |
| SCHEMBL2764624 | 0.84 | PARP1 (0.75) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176237-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | AstraZeneca AB (SE) | 2010-04-21 | — | — | EP | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| WO-2009004356-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009004356-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | NR0B2, NR0B1, NR2E1 | PARP1 3750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.