Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 2/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582097 | 0.90 | CYP11B1 (0.45) | CYP11B1CYP11B2RORCHRH3RXFP1 | |
| Hydrochloric Acid SCHEMBL3568030 | 0.89 | CYP11B1 (0.45) | CYP11B1CYP11B2RORCHRH3RXFP1 | |
| SCHEMBL3573721 | 0.87 | RORC (0.44) | CYP11B1CYP11B2MAPTTHRBLMNA | |
| SCHEMBL3572522 | 0.85 | CYP11B1 (0.44) | CYP11B1CYP11B2RORCRXFP1FNTA | |
| Hydrochloric Acid SCHEMBL3569672 | 0.84 | CYP11B1 (0.43) | CYP11B1CYP11B2RORCRXFP1FNTA | |
| SCHEMBL5226815 | 0.83 | CYP11B1 (0.34) | CYP11B1CYP11B2MAPTTHRBLMNA | |
| SCHEMBL3577749 | 0.79 | CYP11B1 (0.65) | CYP11B1CYP11B2MAPTTHRBLMNA | |
| Hydrochloric Acid SCHEMBL3565591 | 0.78 | CYP11B1 (0.64) | CYP11B1CYP11B2MAPTTHRBLMNA | |
| SCHEMBL3569595 | 0.78 | CYP11B1 (0.53) | CYP11B1CYP11B2MAPTTHRBRORC | |
| SCHEMBL8360362 | 0.78 | CYP11B1 (0.45) | CYP11B1CYP11B2FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1688583-A | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2005-10-26 | — | — | CN | claimed |
| CN-100404535-C | Organic compounds useful as medicaments for the treatment of aldosterone-mediated conditions | NOVARTIS AG (CH) | 2008-07-23 | — | — | CN | disclosed |
| CN-1688583-A | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2005-10-26 | — | — | CN | disclosed |