Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | STK17B | O94768 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450121 | 0.87 | STK17B (0.40) | SIRT5KMT2AMEN1STK17BSTK17A | |
| SCHEMBL28216784 | 0.84 | STK17A (0.53) | SIRT5KMT2AMEN1CA12CA1 | |
| SCHEMBL17595892 | 0.84 | STK17A (0.41) | SIRT5KMT2AMEN1STK17BSTK17A | |
| SCHEMBL1774700 | 0.81 | KMT2A (0.43) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL3873064 | 0.80 | STK17B (0.53) | SIRT5KMT2AMEN1STK17BSTK17A | |
| SCHEMBL25231087 | 0.79 | JAK3 (0.43) | SIRT5KMT2ACA12CA1CA2 | |
| SCHEMBL1774178 | 0.79 | GLP1R (0.45) | KMT2AMEN1CA12CA9CA14 | |
| SCHEMBL13649013 | 0.79 | STK17B (0.46) | SIRT5KMT2AMEN1CA12CA1 | |
| SCHEMBL27087775 | 0.78 | KMT2A (0.46) | SIRT5KMT2ASTK17BSTK17AKDM4E | |
| SCHEMBL30800589 | 0.78 | KMT2A (0.46) | SIRT5KMT2ASTK17BSTK17AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1717396-A | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AG (DE) | 2006-01-04 | — | — | CN | disclosed |