Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.63 |
| ▸ | KIT | P10721 | 18/20 | 0.63 |
| ▸ | FLT3 | P36888 | 12/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5301508 | 0.85 | KDR (0.62) | KDRKITFLT3SRCABL1 | |
| SCHEMBL6800761 | 0.84 | KDR (0.60) | KDRKITFLT3SRCABL1 | |
| SCHEMBL28757596 | 0.84 | KDR (0.60) | KDRKITFLT3SRCABL1 | |
| SCHEMBL27636423 | 0.84 | KDR (0.60) | KDRKITFLT3SRCABL1 | |
| SCHEMBL28757593 | 0.82 | KDR (0.53) | KDRKITFLT3SRCABL1 | |
| SCHEMBL5311742 | 0.81 | KDR (0.52) | KDRKITFLT3SRCABL1 | |
| SCHEMBL27657353 | 0.81 | KDR (0.62) | KDRKITFLT3SRCABL1 | |
| SCHEMBL27657322 | 0.81 | KDR (0.52) | KDRKITFLT3SRCABL1 | |
| SCHEMBL27791459 | 0.81 | KDR (0.62) | KDRKITFLT3SRCABL1 | |
| SCHEMBL5306431 | 0.81 | KDR (0.59) | KDRKITFLT3SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | disclosed |