Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CD38 | P28907 | 4/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571374 | 0.68 | HDAC8 (0.50) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL17701204 | 0.67 | DYRK1A (0.41) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL17701181 | 0.67 | DYRK1A (0.41) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL6260 | 0.65 | DYRK1A (0.43) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL18437163 | 0.65 | HDAC8 (0.31) | DYRK1AHDAC8 | |
| SCHEMBL48894 | 0.64 | DYRK1A (0.55) | DYRK1ADYRK2DYRK1BMAPTCD38 | |
| SCHEMBL1872880 | 0.64 | DYRK1A (0.55) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL3609293 | 0.64 | DYRK1A (0.46) | DYRK1ADYRK2DYRK1BMAPTCD38 | |
| SCHEMBL17701217 | 0.64 | DYRK1A (0.46) | DYRK1ADYRK2DYRK1BMAPTHDAC8 | |
| SCHEMBL17701233 | 0.63 | DYRK1A (0.41) | DYRK1ADYRK2DYRK1BMAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | claimed |
| CN-1829721-A | Spiro '1-azabicyclo' 2.2.2! octan-3,5'-oxazolidin - 2'-one! derivatives with affinity to the alpha7 nicotinic acetylcholine receptor | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | disclosed |