Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | CTSC | P53634 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27636611 | 0.86 | CYP1A2 (0.49) | GSK3BGSK3ACNR2SYKEGFR | |
| SCHEMBL4774405 | 0.85 | GSK3B (0.48) | GSK3BGSK3ACTSCCNR2SYK | |
| SCHEMBL27617470 | 0.82 | SYK (0.47) | CNR2SYKEGFRJAK3AURKA | |
| SCHEMBL4765161 | 0.80 | GSK3A (0.45) | GSK3BGSK3ACTSCSYKEGFR | |
| SCHEMBL4775386 | 0.74 | AURKA (0.49) | GSK3BGSK3ASYKEGFRMAP4K4 | |
| SCHEMBL4772172 | 0.70 | GSK3B (0.51) | GSK3BGSK3ASYKEGFRMAP4K4 | |
| SCHEMBL4775316 | 0.70 | JAK2 (0.46) | GSK3BGSK3ACTSCSYKEGFR | |
| SCHEMBL4764831 | 0.70 | EGFR (0.51) | GSK3BGSK3ASYKEGFRMAP4K4 | |
| SCHEMBL4773983 | 0.70 | GSK3B (0.45) | GSK3BGSK3ASYKEGFRMAP4K4 | |
| SCHEMBL4766694 | 0.69 | SYK (0.50) | SYKEGFRJAK3AURKABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100420687-C | Pyrido [2, 3-D ] pyrimidine derivatives as selective KDR and FGFR inhibitors | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | CN | claimed |
| CN-1729189-A | Pyrido [2, 3-D ] pyrimidine derivatives as selective KDR and FGFR inhibitors | HOFFMANN LA ROCHE (CH) | 2006-02-01 | — | — | CN | claimed |
| CN-100420687-C | Pyrido [2, 3-D ] pyrimidine derivatives as selective KDR and FGFR inhibitors | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | CN | disclosed |
| CN-1729189-A | Pyrido [2, 3-D ] pyrimidine derivatives as selective KDR and FGFR inhibitors | HOFFMANN LA ROCHE (CH) | 2006-02-01 | — | — | CN | disclosed |