Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 6/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765299 | 0.93 | SYK (0.49) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4774864 | 0.91 | CHEK1 (0.50) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4772107 | 0.86 | MAPK8 (0.57) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4775386 | 0.86 | AURKA (0.49) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL27617470 | 0.85 | SYK (0.47) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4770594 | 0.84 | MAPK9 (0.51) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4771624 | 0.84 | CHEK1 (0.46) | SYKMAPK8MAPK9EGFRCHEK1 | |
| SCHEMBL4764815 | 0.84 | CHEK1 (0.49) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4773873 | 0.83 | MAPK8 (0.51) | SYKMAPK8MAPK9EGFRJAK3 | |
| SCHEMBL4769925 | 0.82 | AURKA (0.48) | SYKMAPK8MAPK9EGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |