Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27641209 | 0.87 | HTR6 (0.60) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL27636796 | 0.85 | HTR6 (0.59) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL27641192 | 0.81 | HTR6 (0.61) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL27641198 | 0.81 | AKR1C3 (0.61) | HTR6 | |
| SCHEMBL3559034 | 0.80 | HTR6 (0.55) | HTR6 | |
| SCHEMBL27622283 | 0.80 | HTR6 (0.69) | HTR6 | |
| SCHEMBL14883906 | 0.76 | KDM4E (0.64) | HTR6 | |
| SCHEMBL947498 | 0.76 | KDM4E (0.60) | HTR6 | |
| SCHEMBL947647 | 0.76 | HTR6 (0.74) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL949279 | 0.75 | HTR6 (0.72) | HTR6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101544592-B | Process for preparation of N-arylsulfonyl-3-substituted indoles | SUVEN LIFE SCIENCES LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-1720225-B | N-arylsulfonyl-3-substituted indoles having 5-hydroxytryptamine receptor affinity, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101544592-A | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | SUVEN LIFE SCIENCES LTD (IN) | 2009-09-30 | — | — | CN | disclosed |
| CN-100378109-C | Tetracyclic 3-substituted indoles having serotonin receptor affinity | SUVEN LIFE SCIENCES LTD (IN) | 2008-04-02 | — | — | CN | disclosed |
| CN-1729197-A | Tetracyclic 3-substituted indoles having serotonin receptor affinity | SUVEN LIFE SCIENCES LTD (IN) | 2006-02-01 | — | — | CN | disclosed |
| CN-1720225-A | N-arylsulfonyl-3-substituted indoles having 5-hydroxytryptamine receptor affinity, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LTD (IN) | 2006-01-11 | — | — | CN | disclosed |