Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1519495 | 0.85 | TP53 (0.55) | TP53MAOBROCK2ADORA2AADORA1 | |
| SCHEMBL17594551 | 0.82 | TP53 (0.44) | TP53MAOBROCK2 | |
| SCHEMBL24239390 | 0.82 | TP53 (0.44) | TP53MAOBROCK2 | |
| SCHEMBL5015706 | 0.82 | ESR2 (0.49) | TP53MAOB | |
| SCHEMBL17443379 | 0.81 | TP53 (0.55) | TP53MAOB | |
| SCHEMBL7357666 | 0.81 | EPHX2 (0.43) | — | |
| SCHEMBL31277829 | 0.81 | ROCK2 (0.48) | TP53ROCK2HDAC1HDAC2 | |
| SCHEMBL28685553 | 0.81 | ROCK2 (0.48) | TP53ROCK2HDAC1HDAC2 | |
| SCHEMBL10205890 | 0.80 | TP53 (0.56) | TP53MAOBROCK2ADORA2AADORA1 | |
| SCHEMBL4980691 | 0.78 | TP53 (0.53) | TP53MAOBROCK2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116601150-A | Fused bicyclic RAF inhibitors and methods of use thereof | 爵士制药爱尔兰有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-102159562-A | Chromene modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO | 2011-08-17 | — | — | CN | disclosed |
| CN-1863799-B | Chromancarboxylic acid derivatives for the treatment of diabetes and lipid disorders | SK CORP | 2010-09-22 | — | — | CN | disclosed |
| CN-1863799-A | Chromancarboxylic acid derivatives for the treatment of diabetes and lipid disorders | SK CORP (KR) | 2006-11-15 | — | — | CN | disclosed |