Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL11969543 | 1.00 | NOS2 (0.33) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL1887229 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL28236094 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL7041491 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL1887225 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL28397150 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL27803017 | 0.93 | NOS2 (0.38) | NOS2PRCPNOS3NOS1MEN1 | |
| Threonine SCHEMBL28072332 | 0.93 | — | — | |
| Isoleucine SCHEMBL6534831 | 0.93 | DPP4 (0.34) | PRCPDPP7DPP4DPP8DPP9 | |
| Threonine SCHEMBL6520771 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | claimed |
| CN-114574536-A | Collagen tripeptide and enzymatic preparation method thereof | 华南理工大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-1889974-B | Oligopeptides as coating material for medical products | HEMOTEQ GMBH | 2012-08-29 | — | — | CN | disclosed |
| CN-1889974-A | Oligopeptides as coating material for medical products | HEMOTEQ GMBH (DE) | 2007-01-03 | — | — | CN | disclosed |