Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 4/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438269 | 0.82 | PNMT (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6PNMT | |
| SCHEMBL3964711 | 0.81 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL28517671 | 0.75 | EED (0.56) | EEDHRH4HRH3CHRNB2CHRNA4 | |
| SCHEMBL3466544 | 0.75 | EED (0.56) | EEDSLC6A4SLC6A2SLC6A3HRH4 | |
| SCHEMBL19908818 | 0.75 | EED (0.56) | EEDSLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL3466546 | 0.75 | EED (0.56) | EEDSLC6A4SLC6A2SLC6A3HRH4 | |
| SCHEMBL11633199 | 0.75 | EED (0.56) | EEDSLC6A2HRH4HRH3CHRNB2 | |
| SCHEMBL2089816 | 0.74 | PNMT (0.42) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL8162983 | 0.73 | EED (0.64) | EEDKCNH2HRH4HRH3HTR2C | |
| SCHEMBL8151654 | 0.73 | EED (0.64) | EEDKCNH2HRH4HRH3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |