Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27644640 | 0.83 | NPC1 (0.55) | NPC1RAB9ALMNASTAT3SMN1; SMN2 | |
| SCHEMBL2094618 | 0.82 | MAPT (0.46) | NPC1RAB9ALMNASTAT3PHGDH | |
| SCHEMBL27666152 | 0.81 | SCD (0.53) | NPC1RAB9ALMNASTAT3SMN1; SMN2 | |
| SCHEMBL5243401 | 0.81 | RAB9A (0.63) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL27645217 | 0.76 | RAB9A (0.63) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL27644895 | 0.74 | NPC1 (0.52) | NPC1RAB9ALMNASTAT3SMN1; SMN2 | |
| SCHEMBL12474738 | 0.73 | RAB9A (0.63) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL14143880 | 0.73 | RAB9A (0.63) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL15223295 | 0.73 | NPC1 (0.51) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL11742115 | 0.73 | TP53 (0.42) | NPC1RAB9ALMNASTAT3PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |