Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 4/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14046063 | 0.94 | KCNH2 (0.49) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL14046109 | 0.90 | KCNH2 (0.46) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL27666030 | 0.83 | KCNH2 (0.54) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL9664457 | 0.79 | KCNH2 (0.46) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL9153358 | 0.79 | IDO1 (0.42) | KCNH2IDO1AGXTSLC6A2SLC6A3 | |
| SCHEMBL16234241 | 0.79 | IDO1 (0.48) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL6683227 | 0.79 | MAOB (0.44) | KCNH2MAOBIDO1AGXTTAAR1 | |
| SCHEMBL11005834 | 0.79 | IDO1 (0.48) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL9664449 | 0.79 | KCNH2 (0.46) | KCNH2MAOBIDO1AGXTSLC6A2 | |
| SCHEMBL1051791 | 0.79 | MAOB (0.44) | KCNH2MAOBIDO1AGXTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497345-C | 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2009-06-10 | — | — | CN | disclosed |
| CN-1878777-A | 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis | OTSUKA PHARMA CO LTD (JP) | 2006-12-13 | — | — | CN | disclosed |