Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 20/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13895166 | 0.83 | DRD4 (0.71) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7366679 | 0.81 | DRD4 (0.63) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5666784 | 0.80 | DRD4 (0.66) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23860111 | 0.80 | DRD4 (0.66) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9385194 | 0.80 | DRD4 (0.78) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23919027 | 0.79 | DRD4 (0.64) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7371617 | 0.79 | DRD4 (0.76) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7262675 | 0.79 | DRD4 (0.76) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL11973909 | 0.79 | DRD4 (0.76) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4690091 | 0.78 | DRD4 (0.71) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1878762-B | Morpholine derivatives as norepinephrine reuptake inhibitors | LILLY CO ELI | 2010-10-27 | — | — | CN | disclosed |
| CN-1878762-A | Morpholine derivatives as norepinephrine reuptake inhibitors | LILLY CO ELI (US) | 2006-12-13 | — | — | CN | disclosed |