Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28304455 | 0.84 | AOC3 (0.47) | POLBAOC3MEN1KMT2AHTT | |
| SCHEMBL28146646 | 0.81 | RIPK1 (0.49) | POLBRECQLRIPK1MEN1KMT2A | |
| SCHEMBL27493606 | 0.75 | MAOB (0.41) | POLBRECQLAOC3RIPK1MEN1 | |
| SCHEMBL23803543 | 0.74 | RIPK1 (0.60) | POLBRECQLRIPK1MEN1KMT2A | |
| SCHEMBL23819888 | 0.74 | RIPK1 (0.46) | POLBRECQLRIPK1MEN1KMT2A | |
| Bromide SCHEMBL9551291 | 0.72 | POLB (0.51) | POLBRECQLAOC3RIPK1MEN1 | |
| SCHEMBL8773482 | 0.71 | MEN1 (0.69) | RECQLRIPK1MEN1KMT2AHTT | |
| SCHEMBL27292941 | 0.70 | AOC3 (0.58) | AOC3NPC1RAB9ACA12CA9 | |
| SCHEMBL2061999 | 0.70 | AKT1 (0.50) | AOC3RIPK1MEN1KMT2AHTT | |
| SCHEMBL8256930 | 0.70 | SMN1; SMN2 (0.65) | POLBRECQLMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100422179-C | 2-amino-5-benzoylthiazole npy antagonists | HOFFMANN LA ROCHE (CH) | 2008-10-01 | — | — | CN | disclosed |
| CN-1852907-A | 2-amino-5-benzoylthiazole npy antagonists | HOFFMANN LA ROCHE (CH) | 2006-10-25 | — | — | CN | disclosed |