Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | TXK | P42681 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623341 | 0.90 | ITK (0.63) | ITKLCKTXKSYKCSNK2A1 | |
| SCHEMBL1620556 | 0.90 | ITK (0.51) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1623956 | 0.86 | ITK (0.58) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL1622112 | 0.80 | ITK (0.55) | ITKLCKTXKSYKCSNK2A1 | |
| SCHEMBL1622817 | 0.80 | ITK (0.65) | ITKLCKTXKSYK | |
| SCHEMBL1622468 | 0.79 | ITK (0.57) | ITKLCKTXKSYKPARP1 | |
| SCHEMBL1627170 | 0.78 | NPC1 (0.48) | ITKLCKTXKSYKMAPK1 | |
| SCHEMBL1628603 | 0.78 | ITK (0.62) | ITKLCKTXKSYKCHEK1 | |
| SCHEMBL4125482 | 0.78 | ITK (0.81) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL1623125 | 0.77 | ITK (0.50) | ITKLCKTXKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100398545-C | Thienopyrazoles | AVENTIS PHARMA INC (US) | 2008-07-02 | — | — | CN | claimed |
| CN-1849322-A | Thienopyrazoles | AVENTIS PHARMA INC (US) | 2006-10-18 | — | — | CN | claimed |