Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715115 | 0.88 | KDR (0.47) | PDE5AFLT1KDR | |
| SCHEMBL1715441 | 0.82 | KDM4C (0.48) | PDE5AEPHB4FLT1KDRKDM4E | |
| SCHEMBL1715615 | 0.82 | POLB (0.44) | PDE5AEPHB4FLT1KDRALDH1A1 | |
| SCHEMBL1715211 | 0.81 | KDR (0.47) | PDE5AEPHB4FLT1KDR | |
| SCHEMBL1715709 | 0.80 | ALDH1A1 (0.42) | PDE5AEPHB4FLT1KDRALDH1A1 | |
| SCHEMBL1714727 | 0.77 | KDR (0.42) | EPHB4FLT1KDRALDH1A1TSHR | |
| SCHEMBL27668371 | 0.75 | KDM4C (0.41) | PDE5AEPHB4FLT1KDRALDH1A1 | |
| SCHEMBL1715778 | 0.75 | KDR (0.53) | FLT1KDR | |
| SCHEMBL1714870 | 0.75 | TSHR (0.46) | PDE5AEPHB4FLT1KDRALDH1A1 | |
| SCHEMBL1714924 | 0.75 | KDR (0.48) | FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1906155-A | Novel hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA AS (DK) | 2007-01-31 | — | — | CN | claimed |
| CN-1906155-A | Novel hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA AS (DK) | 2007-01-31 | — | — | CN | disclosed |