Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 15/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648484 | 0.83 | TGFBR1 (0.52) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL28758711 | 0.78 | TGFBR1 (0.45) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL28756497 | 0.78 | LRRK2 (0.37) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL2875294 | 0.78 | CCR1 (0.54) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL5200287 | 0.77 | MEN1 (0.40) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL5491962 | 0.77 | TGFBR1 (0.56) | METAP2CCR1CCR8TGFBR1MAPK14 | |
| SCHEMBL5494094 | 0.77 | TGFBR1 (0.56) | METAP2CCR1CCR8TGFBR1CYP2A6 | |
| SCHEMBL12645997 | 0.76 | TGFBR1 (0.61) | CCR1CCR8TGFBR1MAPK14THRB | |
| SCHEMBL16050442 | 0.75 | CHEK1 (0.30) | — | |
| SCHEMBL5492614 | 0.74 | TGFBR1 (0.58) | METAP2CCR1CCR8TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1770980-A | Pyrazoles and methods of making and using the same | BIOGEN IDEC INC (US) | 2006-05-10 | — | — | CN | claimed |