Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Bromobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromobenzene SCHEMBL27649869 | 0.87 | ALDH1A1 (0.44) | ALDH1A1TDP1PSIP1TSHRSMN1; SMN2 | |
| Bromobenzene SCHEMBL27813453 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRSMN1; SMN2EGFR | |
| Bromobenzene SCHEMBL28758815 | 0.84 | TDP1 (0.41) | ALDH1A1TDP1TSHRSMN1; SMN2HSD11B1 | |
| Bromobenzene SCHEMBL28433062 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TDP1PSIP1TSHRHSD11B1 | |
| Biphenyl SCHEMBL27706380 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1PSIP1TSHRSMN1; SMN2HTT | |
| Bromobenzene SCHEMBL3959965 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRSMN1; SMN2HSD11B1 | |
| Bromobenzene SCHEMBL9283182 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRSMN1; SMN2HSD11B1 | |
| Bromobenzene SCHEMBL9128632 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRSMN1; SMN2HSD11B1 | |
| Bromobenzene SCHEMBL19859280 | 0.79 | ALDH1A1 (0.65) | ALDH1A1TDP1TSHRSMN1; SMN2MAPK1 | |
| Bromobenzene SCHEMBL27559092 | 0.79 | ALDH1A1 (0.65) | ALDH1A1TDP1PSIP1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100381421-C | Process for producing triarylsulfonium salt | WAKO PURE CHEM IND LTD (JP) | 2008-04-16 | — | — | CN | disclosed |
| CN-1871212-A | Process for producing triarylsulfonium salt | WAKO PURE CHEM IND LTD (JP) | 2006-11-29 | — | — | CN | disclosed |