Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27629337 | 1.00 | HRH1 (0.59) | HRH1JAK3HDAC6CREBBPDRD2 | |
| SCHEMBL10199697 | 0.81 | HTR2A (0.45) | HRH1NOS3NOS1NOS2HTR2A | |
| SCHEMBL27629340 | 0.81 | HRH1 (0.40) | HRH1NOS3NOS1NOS2HTR2A | |
| SCHEMBL5016356 | 0.81 | HTR2A (0.45) | HRH1NOS3NOS1NOS2HTR2A | |
| SCHEMBL27649431 | 0.78 | HRH1 (0.38) | HRH1DRD2HTR2ASMN1; SMN2 | |
| SCHEMBL14197429 | 0.77 | HRH1 (0.52) | HRH1HDAC6DRD2HTR1A | |
| SCHEMBL4862162 | 0.77 | HRH1 (0.49) | HRH1JAK3HDAC6CREBBPDRD2 | |
| SCHEMBL11359103 | 0.76 | HRH1 (0.58) | HRH1JAK3HDAC6CREBBPDRD2 | |
| Hydrochloric Acid SCHEMBL6625464 | 0.74 | HRH1 (0.37) | HRH1CREBBPALDH1A1 | |
| SCHEMBL14197457 | 0.73 | HRH1 (0.49) | HRH1JAK3HDAC6CREBBPDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1780612-B | Treatment of incontinence with 5HT2C agonists. | PFIZER | 2010-12-01 | — | — | CN | disclosed |
| CN-1780612-A | Treatment of incontinence with 5HT2C agonists. | PFIZER (US) | 2006-05-31 | — | — | CN | disclosed |