Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.51 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.51 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521430 | 0.98 | CDK4 (0.60) | CDK4CCND1ALDH1A1GLANPC1 | |
| SCHEMBL22138645 | 0.91 | CDK4 (0.53) | CDK4CCND1ALDH1A1GLANPC1 | |
| SCHEMBL13794253 | 0.84 | CDK4 (0.51) | CDK4CCND1ALDH1A1GLANPC1 | |
| SCHEMBL15936149 | 0.84 | CDK4 (0.55) | CDK4CCND1ALDH1A1GLATDP1 | |
| SCHEMBL4103628 | 0.84 | ALDH1A1 (0.49) | CDK4CCND1ALDH1A1GLANPC1 | |
| SCHEMBL13144446 | 0.84 | ABCB1 (0.60) | CDK4CCND1TSHRMAPK1TDP1 | |
| SCHEMBL5645243 | 0.82 | CDK4 (0.54) | CDK4CCND1HTR1AADRA1DADRA1A | |
| SCHEMBL1539377 | 0.82 | CDK4 (0.46) | CDK4CCND1ALDH1A1GLANPC1 | |
| SCHEMBL12301130 | 0.82 | MAPT (0.56) | CDK4CCND1ALDH1A1NPC1RAB9A | |
| SCHEMBL28665029 | 0.82 | CDK4 (0.54) | CDK4CCND1ALDH1A1GLANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946666-A | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders | AMGEN INC (US) | 2007-04-11 | — | — | CN | disclosed |