Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263313 | 0.80 | GPR119 (0.79) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL1674033 | 0.78 | GPR119 (0.77) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL389430 | 0.78 | GPR119 (1.00) | GPR119MAPTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL1674020 | 0.78 | GPR119 (0.76) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL6041132 | 0.77 | MAPT (0.39) | GPR119MAPTHTTNPC1SMN1; SMN2 | |
| SCHEMBL386160 | 0.76 | GPR119 (0.74) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL386159 | 0.76 | GPR119 (0.73) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL1674095 | 0.76 | GPR119 (0.73) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL388589 | 0.75 | GPR119 (0.72) | GPR119MAPTLMNAHPGDALDH1A1 | |
| SCHEMBL389482 | 0.75 | GPR119 (0.72) | GPR119MAPTLMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1835943-A | 1,2, 3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prevention and treatment of diseases related thereto, such as diabetes and hyperglycemia | ARENA PHARM INC (US) | 2006-09-20 | — | — | CN | disclosed |