Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28942861 | 0.95 | HDAC1 (0.58) | HDAC1HDAC8HDAC6NAMPTHPGD | |
| SCHEMBL27652918 | 0.77 | HDAC6 (0.54) | HDAC1HDAC8HDAC6NAMPTHPGD | |
| SCHEMBL27672991 | 0.76 | IKBKE (0.47) | HDAC1HDAC8HDAC6NAMPTHPGD | |
| SCHEMBL8809936 | 0.76 | HDAC1 (0.68) | HDAC1HDAC8HDAC6NAMPTKMT2A | |
| SCHEMBL27673031 | 0.74 | NPC1 (0.54) | RAB9ANPC1 | |
| SCHEMBL8806829 | 0.74 | HDAC1 (0.65) | HDAC1RAB9ANPC1SSTR3 | |
| SCHEMBL27652919 | 0.73 | HDAC6 (0.57) | HDAC1HDAC8HDAC6HPGDKMT2A | |
| SCHEMBL27672992 | 0.73 | HDAC1 (0.61) | HDAC1HDAC8HDAC6HPGDKMT2A | |
| SCHEMBL29056584 | 0.73 | HDAC1 (0.59) | HDAC1HPGDKMT2ARAB9ASSTR3 | |
| SCHEMBL22917363 | 0.72 | MCHR1 (0.48) | KMT2ARAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | claimed |
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | disclosed |