Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27652917 | 0.86 | HDAC6 (0.49) | IKBKETBK1NPC1RAB9AHDAC1 | |
| SCHEMBL27672996 | 0.80 | KCNK3 (0.57) | NPC1RAB9AHDAC1NAMPTHPGD | |
| SCHEMBL19197479 | 0.80 | TRPV1 (0.61) | NPC1RAB9AHDAC1HDAC3HDAC2 | |
| SCHEMBL27652918 | 0.80 | HDAC6 (0.54) | NPC1RAB9AHDAC1HDAC3NAMPT | |
| SCHEMBL17076673 | 0.78 | POLB (0.67) | LSSNPC1RAB9AHDAC1HDAC3 | |
| SCHEMBL27652925 | 0.76 | HDAC1 (0.53) | NPC1RAB9AHDAC1NAMPTHPGD | |
| SCHEMBL27652926 | 0.76 | KDM4E (0.47) | NPC1RAB9AHDAC1NAMPTHPGD | |
| SCHEMBL27652921 | 0.74 | KMT2A (0.57) | NPC1RAB9ANAMPTHPGDKCNK3 | |
| SCHEMBL28472008 | 0.74 | HPGD (0.53) | NPC1RAB9AHDAC1NAMPTHPGD | |
| SCHEMBL27652922 | 0.74 | PTPN1 (0.61) | NPC1RAB9ANAMPTHPGDKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | claimed |
| CN-1946395-A | 1H-thieno [2, 3-c ] pyrazole derivatives useful as kinase inhibitors | PHARMACIA ITALIA SPA (IT) | 2007-04-11 | — | — | CN | disclosed |