Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 9/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675173 | 0.89 | MEN1 (0.44) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL5710829 | 0.85 | GRM5 (0.60) | MEN1KMT2AGRM5CYP3A4 | |
| SCHEMBL27655153 | 0.82 | MEN1 (0.48) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27675009 | 0.81 | GRM5 (0.41) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27675030 | 0.81 | CACNA2D1 (0.44) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27655175 | 0.81 | CACNA2D1 (0.46) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27655173 | 0.80 | GRM5 (0.40) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27675078 | 0.80 | GRM5 (0.43) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27655169 | 0.79 | MAPT (0.46) | MEN1POLBKMT2AGRM5CYP3A4 | |
| SCHEMBL27675002 | 0.78 | MAPT (0.47) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | claimed |
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | disclosed |