Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 10/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 10/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 10/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27655169 | 0.89 | MAPT (0.46) | MAPTALDH1A1HTTLMNAKDM4E | |
| SCHEMBL27655175 | 0.87 | CACNA2D1 (0.46) | MAPTALDH1A1HTTLMNACACNA2D1 | |
| SCHEMBL5710807 | 0.86 | GRM5 (0.56) | MAPTALDH1A1HTTLMNA | |
| SCHEMBL27674992 | 0.85 | MAPT (0.42) | MAPTALDH1A1HTTLMNACACNA2D1 | |
| SCHEMBL27675173 | 0.81 | MEN1 (0.44) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL27655170 | 0.80 | CACNA2D1 (0.39) | MAPTALDH1A1HTTLMNACACNA2D1 | |
| SCHEMBL27655174 | 0.79 | — | — | |
| SCHEMBL27655166 | 0.78 | MEN1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1G | |
| SCHEMBL27675030 | 0.78 | CACNA2D1 (0.44) | ALDH1A1LMNASMN1; SMN2CACNA2D1CACNA1B | |
| SCHEMBL27655173 | 0.77 | GRM5 (0.40) | MAPTALDH1A1HTTCACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | claimed |
| CN-1934097-A | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2007-03-21 | — | — | CN | disclosed |