Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.53 |
| ▸ | EIF4H | Q15056 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943481 | 0.86 | HTR1A (0.63) | HTTSMN1; SMN2HDAC6HTR1AADRA1D | |
| SCHEMBL2478157 | 0.80 | MEN1 (0.57) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL2736333 | 0.80 | MEN1 (0.62) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL30504562 | 0.80 | MEN1 (0.57) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL29260245 | 0.80 | MEN1 (0.57) | MEN1KMT2AALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL28828326 | 0.78 | MEN1 (0.56) | MEN1KMT2AALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL6311928 | 0.78 | MEN1 (0.56) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL20027756 | 0.77 | MEN1 (0.58) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL349575 | 0.76 | MEN1 (0.57) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL349576 | 0.76 | MEN1 (0.57) | MEN1KMT2AALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1832925-B | New P2X7 receptor avtagonists and their use | ASTRAZENECA AB | 2010-05-05 | — | — | CN | disclosed |
| CN-1832925-A | New p2x7 receptor avtagonists and their use | ASTRAZENECA AB (SE) | 2006-09-13 | — | — | CN | disclosed |
| CN-1829694-A | quinoline derivatives and their use in therapy | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | disclosed |