Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27656049 | 0.99 | RAB9A (0.50) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL27634955 | 0.90 | RAB9A (0.52) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL27634898 | 0.89 | RAB9A (0.51) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL1651258 | 0.88 | RAB9A (0.52) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL27656050 | 0.88 | NR1H4 (0.44) | RAB9ANPC1KMT2AMEN1PTGDR2 | |
| SCHEMBL1651004 | 0.87 | TBXA2R (0.48) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL1010339 | 0.86 | NR1H4 (0.48) | RAB9ANPC1KMT2AMEN1PTGDR2 | |
| SCHEMBL1226565 | 0.85 | PTGDR2 (0.56) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL1227036 | 0.84 | PTGDR2 (0.57) | RAB9ANPC1KMT2AMAPTMEN1 | |
| SCHEMBL27634957 | 0.78 | NR1H4 (0.46) | RAB9ANPC1KMT2AMEN1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101914065-A | Help to treat pyrimidine derivatives by the disease of CRTH2 mediation | ACTIMIS PHARMACEUTICALS INC | 2010-12-15 | — | — | CN | claimed |
| CN-1809539-A | Pyrimidine derivatives useful in the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-07-26 | — | — | CN | claimed |
| CN-101914065-A | Help to treat pyrimidine derivatives by the disease of CRTH2 mediation | ACTIMIS PHARMACEUTICALS INC | 2010-12-15 | — | — | CN | disclosed |
| CN-1809539-A | Pyrimidine derivatives useful in the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2006-07-26 | — | — | CN | disclosed |