Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9362645 | 0.93 | PTPN1 (0.48) | PTPN1SMPD1LPAR6LPAR1LPAR4 | |
| SCHEMBL9367572 | 0.93 | PTPN1 (0.48) | PTPN1SMPD1LPAR6LPAR1LPAR4 | |
| SCHEMBL27627196 | 0.93 | PTPN1 (0.48) | PTPN1SMPD1LPAR6LPAR1LPAR4 | |
| SCHEMBL9362627 | 0.93 | PTPN1 (0.48) | PTPN1SMPD1LPAR6LPAR1LPAR4 | |
| Monoethanolamine SCHEMBL27676043 | 0.93 | LPAR3 (0.46) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL27504160 | 0.86 | LPAR1 (0.50) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL7454857 | 0.86 | LPAR1 (0.50) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| Phosphoric Acid SCHEMBL29050544 | 0.85 | MAPT (0.48) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL30441738 | 0.84 | PTPN1 (0.45) | PTPN1SMPD1LPAR6LPAR1LPAR4 | |
| SCHEMBL15022342 | 0.84 | PLA2G2C (0.46) | LPAR6LPAR1LPAR4LPAR5LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100551365-C | The method for preparing submicron particles of antineoplastic agents | BAXTER INT (US) | 2009-10-21 | — | — | CN | disclosed |
| CN-101309707-A | Composition comprising lipoxygenase inhibitor and cyclodextrin | BAXTER INT (US) | 2008-11-19 | — | — | CN | disclosed |
| CN-1870987-A | Process for preparing submicron particles of paclitaxel | BAXTER INT (US) | 2006-11-29 | — | — | CN | disclosed |