Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acrylic Acid Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid Methyl Ester SCHEMBL27504128 | 0.90 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL27567444 | 0.90 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL3668715 | 0.90 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL27656093 | 0.90 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL28844449 | 0.90 | TSHR (0.37) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL27656092 | 0.88 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL27900027 | 0.88 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL27900025 | 0.88 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL28102363 | 0.88 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL28183339 | 0.86 | HCAR2 (0.42) | HCAR2KEAP1NFE2L2TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104302739-B | The method of the flushing liquor system in process coke-oven plant | 通用电气公司 | 2016-06-29 | — | — | CN | claimed |
| CN-104302739-A | A method to treat flushing liquor systems in coke plants | GEN ELECTRIC | 2015-01-21 | — | — | CN | claimed |
| CN-104302739-B | The method of the flushing liquor system in process coke-oven plant | 通用电气公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-105189707-A | Process, method, and system for removing heavy metals from oily solids | CHEVRON USA INC | 2015-12-23 | — | — | CN | disclosed |
| CN-104302739-A | A method to treat flushing liquor systems in coke plants | GEN ELECTRIC | 2015-01-21 | — | — | CN | disclosed |
| CN-100363062-C | Active substance-doped absorbent polymer particles, composition comprising a polycondensate matrix and an absorbent polymer for releasing a wound treatment substance | STOCKHAUSEN CHEM FAB GMBH (DE) | 2008-01-23 | — | — | CN | disclosed |
| CN-1819848-A | Active substance-doped absorbent polymer particles, composition comprising a polycondensate matrix and an absorbent polymer for releasing a wound treatment substance | STOCKHAUSEN CHEM FAB GMBH (DE) | 2006-08-16 | — | — | CN | disclosed |
| CN-1659134-A | Monomer compound comprising several cationic groups, method for the production thereof and polymer comprising units derived from said monomer compound | RHODIA (US) | 2005-08-24 | — | — | CN | disclosed |