Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acrylic Acid Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.32 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid Methyl Ester SCHEMBL27656259 | 0.90 | HCAR2 (0.42) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL28290745 | 0.86 | TSHR (0.43) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27485144 | 0.84 | TSHR (0.42) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27534798 | 0.82 | TSHR (0.38) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27567444 | 0.81 | HCAR2 (0.46) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27656093 | 0.81 | HCAR2 (0.46) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL3668715 | 0.81 | HCAR2 (0.46) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27504128 | 0.81 | HCAR2 (0.46) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL27656092 | 0.79 | HCAR2 (0.40) | TSHRHPGDHCAR2KEAP1NFE2L2 | |
| Acrylic Acid Methyl Ester SCHEMBL6061216 | 0.79 | TSHR (0.45) | TSHRHPGDHCAR2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105338953-B | Method for achieving improved product rheology, cosmetic consumer acceptance and deposition | 宝洁公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-107106456-A | Method for improving volume and combability using personal care compositions comprising pre-emulsified formulations | 宝洁公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-106794128-A | Using the anti-dandruff personal care composition comprising pre-emulsification preparation realize volume and can cardability improve method | 宝洁公司 | 2017-05-31 | — | — | CN | disclosed |