Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27766174 | 0.83 | ALDH1A1 (0.40) | ALDH1A1POLBHPGDHSD17B10TP53 | |
| Ethoxycarbonyl Group SCHEMBL27495906 | 0.83 | ALDH1A1 (0.40) | ALDH1A1POLBHPGDHSD17B10TP53 | |
| Acetaldehyde SCHEMBL27471636 | 0.82 | ALDH1A1 (0.43) | ALDH1A1POLBHPGDMAPTHTT | |
| Ether SCHEMBL20527592 | 0.80 | ALDH1A1 (0.42) | ALDH1A1POLBHPGDHSD17B10TP53 | |
| SCHEMBL28542440 | 0.80 | ALDH1A1 (0.41) | ALDH1A1POLBHPGDTSHRCHRM2 | |
| Ethoxycarbonyl Group SCHEMBL28772964 | 0.79 | ALDH1A1 (0.35) | ALDH1A1POLBHPGDHSD17B10TP53 | |
| SCHEMBL281641 | 0.78 | — | — | |
| Furfural SCHEMBL28172662 | 0.76 | ALDH1A1 (0.64) | ALDH1A1POLBHPGDHSD17B10MAPT | |
| Ethoxycarbonyl Group SCHEMBL27691649 | 0.76 | ALDH1A1 (0.35) | ALDH1A1POLBHPGDHSD17B10TP53 | |
| SCHEMBL27885653 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153179-B | 4 β furoyl amine podophyllotoxin derivatives and preparation method and application | 中国人民武装警察部队后勤学院 | 2017-05-31 | — | — | CN | disclosed |
| CN-104230827-B | 1-(aryl methyl) quinazoline-2,4 (1H, 3H)-diketone is as PARP inhibitor and application thereof | 南京英派药业有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-105153179-A | 4 beta-furoylamide type podophyllotoxin derivative as well as preparation method and application thereof | MEDICAL COLLEGE CAPF | 2015-12-16 | — | — | CN | disclosed |
| CN-104230827-A | 1-(aryl methyl) quinazoline-2,4(1H,3H) diketone used as PARP (Poly-ADP-Ribose Polymerase) inhibitor and application thereof | NANJING IMPACT THERAPEUTICS INC | 2014-12-24 | — | — | CN | disclosed |
| CN-103097361-B | 1- (arylmethyl) quinazoline-2, 4(1H,3H) -diketone serving as PARP inhibitor and application thereof | NANJING IMPACT THERAPEUTICS INC | 2014-08-06 | — | — | CN | disclosed |
| CN-103889976-A | Indazole compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2014-06-25 | — | — | CN | disclosed |
| CN-103304572-A | 3-cyanoquinoline compound as well as pharmaceutical composition and application thereof | SHANGHAI PHARMACEUTICAL GROUP CO LTD | 2013-09-18 | — | — | CN | disclosed |
| CN-103097361-A | 1- (arylmethyl) quinazoline-2, 4(1H,3H) -diketone serving as PARP inhibitor and application thereof | NANJING IMPACT THERAPEUTICS INC | 2013-05-08 | — | — | CN | disclosed |
| CN-100496499-C | Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the RSV fusion protein | ARROW THERAPEUTICS LTD (GB) | 2009-06-10 | — | — | CN | disclosed |
| CN-100447136-C | New spirotricyclic derivatives and their use as phosphodiesterase-7-inhibitors | WARNER LAMBERT CO (US) | 2008-12-31 | — | — | CN | disclosed |
| CN-101233114-A | New imidazole carboxamides, useful to treat e.g. pathologies associated with the insulin resistance syndrome, are fructose-1,6-biphosphatase inhibitors | MERCK PATENT GMBH (DE) | 2008-07-30 | — | — | CN | disclosed |
| CN-1929848-A | Benzodiazepines for treating or preventing or preventing RSV infection | ARROW THERAPEUTICS LTD (GB) | 2007-03-14 | — | — | CN | disclosed |
| CN-1498212-A | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | ��������ʲ��������ι�˾ | 2004-05-19 | — | — | CN | disclosed |