Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | KIT | P10721 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | BCR | P11274 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27657473 | 0.89 | IKBKE (0.51) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL27657311 | 0.88 | KDR (0.56) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL28760142 | 0.87 | KDR (0.58) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL419924 | 0.84 | KDR (0.71) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL27657441 | 0.83 | KDR (0.57) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL27636394 | 0.81 | KDR (0.51) | KDRKITFLT3ABL1BCR | |
| SCHEMBL27657347 | 0.80 | KDR (0.49) | KDRKITFLT3ABL1BCR | |
| SCHEMBL424601 | 0.80 | KDR (0.56) | KDRKITFLT3IKBKEABL1 | |
| SCHEMBL27636391 | 0.77 | KDR (0.49) | KDRKITFLT3ABL1BCR | |
| SCHEMBL27657344 | 0.77 | KDR (0.69) | KDRKITFLT3ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826324-B | indazole, Benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2011-12-07 | — | — | CN | claimed |
| CN-1826324-A | Indazole, benzisoxazole and benzisothiazole kinase inhibitors | ABBOTT LAB (US) | 2006-08-30 | — | — | CN | claimed |
| CN-101827584-A | Solid dispersion product of N-aryl ureido drugs | ABBOTT GMBH & CO KG | 2010-09-08 | — | — | CN | disclosed |